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Alder-Reilly granules are primarily composed of mucopolysaccharides, which are long chains of sugar molecules that play a crucial role in forming connective tissues and are important in various biological functions. The presence of these granules is often associated with certain metabolic disorders, particularly mucopolysaccharidoses, where there is a build-up of, or inability to metabolize, these substances properly.

In the context of hematological evaluations, the identification of Alder-Reilly granules can be significant in differentiating between various types of leukocyte abnormalities and their underlying causes. Recognizing the specific composition of these granules helps in understanding their role within the cell and their implications in patient disease states. Other potential components, such as fibrin, enzymatic proteins, or ribonucleic acids, do not accurately reflect the granules’ chemical structure or biological relevance in the same way that mucopolysaccharides do.